| Team: | Maryland Maniacs |
| Year: | 2010 |
| Record: | 1-13 |
| Division Place: | 4th Atlantic East |
| Coach: | Darryl D'Ateno |
| Owner: | Messay Hailemariam |
| Stadium: | Cole Field House Campus Drive College Park, MD 20742 |
| Playoffs: | did not qualify |
| No Nextseason: | true |
The Maryland Maniacs season was the team's second season as a football franchise and second in the Indoor Football League (IFL). One of twenty-five teams competing in the IFL for the 2010 season, the Maniacs were members of the Atlantic East Division of the United Conference. The team played their home games at Cole Field House in College Park, Maryland.
| Week | Day | Date | Kickoff | Opponent | Results | Location | ||
|---|---|---|---|---|---|---|---|---|
| Final Score | Team Record | |||||||
| 1 | Friday | February 26 | 7:00pm | at West Michigan ThunderHawks | L 36-52 | 0-1 | L. C. Walker Arena | |
| 2 | colSpan=7 align="center" | Bye | ||||||
| 3 | colSpan=7 align="center" | Bye | ||||||
| 4 | Saturday | March 20 | 7:05pm | at Richmond Revolution | L 18-23 | 0-2 | Arthur Ashe Athletic Center | |
| 5 | colSpan=7 align="center" | Bye | ||||||
| 6 | Saturday | April 3 | 7:05pm | Green Bay Blizzard | L 45-46 | 0-3 | Cole Field House | |
| 7 | Sunday | April 11 | 2:05pm | Rochester Raiders | L 36-52 | 0-4 | Cole Field House | |
| 8 | Friday | April 17 | 7:05pm | at Bloomington Extreme | L 69-72 | 0-5 | U.S. Cellular Coliseum | |
| 9 | Saturday | April 24 | 7:05pm | at Richmond Revolution | L 45-54 | 0-6 | Arthur Ashe Athletic Center | |
| 10 | Saturday | May 1 | 7:05pm | Rochester Raiders | L 39-46 | 0-7 | Cole Field House | |
| 11 | Saturday | May 8 | 7:05pm | Richmond Revolution | L 39–55 | 0-8 | Cole Field House | |
| 12 | Saturday | May 15 | 7:30pm | at Rochester Raiders | L 18-51 | 0-9 | Dome Arena | |
| 13 | Saturday | May 22 | 7:00pm | at West Michigan ThunderHawks | L 33-59 | 0-10 | L. C. Walker Arena | |
| 14 | Saturday | May 29 | 7:35pm | at Rochester Raiders | L 9-36 | 0-11 | Dome Arena | |
| 15 | Saturday | June 5 | 7:05pm | Richmond Revolution | L 14-74 | 0-12 | Cole Field House | |
| 16 | Saturday | June 12 | 7:05pm | Bloomington Extreme | L 7-51 | 0-13 | Cole Field House | |
| 17 | Saturday | June 19 | 7:00pm | West Michigan ThunderHawks | W 25-13 | 1-13 | Cole Field House | |