The 2010 Abierto Internacional Varonil Casablanca Cancún was a professional tennis tournament played on clay courts. It was the third edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Cancún, Mexico between 15 and 21 November 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Carlos Berlocq | 75 | 1 | |
 Spain | Pere Riba | 79 | 2 | |
| Spain | Rubén Ramírez Hidalgo | 80 | 3 | |
| Argentina | Brian Dabul | 83 | 4 | |
| Argentina | Horacio Zeballos | 108 | 5 | |
 Slovenia | Grega Žemlja | 122 | 6 | |
| Argentina | Máximo González | 155 | 7 | |
 France | Éric Prodon | 160 | 8 |
The following players received wildcards into the singles main draw:
Daniel Garza César Ramírez
Ty Trombetta
Mark VerrythThe following players received entry as an alternate into the singles main draw:
The following players received entry from the qualifying draw:
Thomas Cazes-Carrère (LL)
Leonardo Kirche Axel MichonSee main article: article and 2010 Abierto Internacional Varonil Casablanca Cancún – Singles. Pere Riba def. Carlos Berlocq, 6–4, 6–0
See main article: article and 2010 Abierto Internacional Varonil Casablanca Cancún – Doubles. 
Víctor Estrella / Santiago González def. 
Rainer Eitzinger / César Ramírez, 6–1, 7–6(3)
