| Competition: | Macedonian Second League |
| Season: | 2010–11 |
| Winners: | 11 Oktomvri |
| Promoted: | 11 Oktomvri Ohrid |
| Relegated: | Novaci Cementarnica Vlaznimi |
| Prevseason: | 2009–10 |
| Nextseason: | 2011–12 |
The 2010–11 Macedonian Second Football League was the nineteenth season since its establishment. It began on 8 August 2010 and ended on 29 May 2011.[1]
| Club | City | Stadium | Capacity | |
|---|---|---|---|---|
| 11 Oktomvri | Prilep | Stadion Goce Delchev | 15,000 | |
| Belasica | Strumica | Stadion Mladost | 6,370 | |
| Cementarnica 55 | Skopje | Stadion Cementarnica | 2,000 | |
| Drita | Bogovinje | Stadion Bogovinje | 500 | |
| Euromilk Gorno Lisiche | Skopje | Stadion Gorno Lisiche | 1,500 | |
| Lokomotiva | Skopje | Stadion Komunalec | 1,000 | |
| Miravci | Miravci | Stadion Miravci | 1,000 | |
| Novaci 2005 | Novaci | Stadion Novaci | 500 | |
| Ohrid 2004 | Ohrid | SRC Biljanini Izvori | 3,000 | |
| Ohrid Lote | Ohrid | SRC Biljanini Izvori | 3,000 | |
| Rinia Gostivar | Gostivar | Gradski stadion Gostivar | 1,000 | |
| Tikvesh | Kavadarci | Gradski Stadion Kavadarci | 7,500 | |
| Vlaznimi | Struga | Stadion Gradska Plazha | 500 | |
| Vëllazërimi | Kichevo | Gradski stadion Kichevo | 5,000 |
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