The 2006 Season was the 20th edition of the United Soccer Leagues season.
| Competition | Champion | Runner-Up | Regular Season Champion/Best USL team |
|---|---|---|---|
| USL First Division | Vancouver Whitecaps | Rochester Raging Rhinos | Montreal Impact |
| USL Second Division | Richmond Kickers | Charlotte Eagles | Richmond Kickers |
| USL PDL | Michigan Bucks | Laredo Heat | Carolina Dynamo |
| U.S. Open Cup | Chicago Fire (MLS) | Los Angeles Galaxy (MLS) | Carolina Dynamo (PDL) |
| Voyageurs Cup | Montreal Impact | Toronto Lynx | n/a |
Quarterfinals and Semifinals 2-game aggregate
Higher seeded team hosted first game
Charleston Battery won 3–2 on Aggregate.----Vancouver Whitecaps won 6–1 on Aggregate.
Rochester Raging Rhinos won 1–0 on Aggregate.----Vancouver Whitecaps won 2–0 on Aggregate in Overtime.
First Team
F: Romario (Miami FC) (Co-Leading Goalscorer); Cam Weaver (Seattle Sounders) (Co-Leading Goalscorer)
M: Ben Hollingsworth (Charleston Battery); Luke Kreamalmeyer (Portland Timbers); Zinho (Miami FC); Joey Gjertsen (Vancouver Whitecaps) (MVP)
D: Gabriel Gervais (Montreal Impact) (Defender of the Year); Geordie Lyall (Vancouver Whitecaps); Mauricio Segovia (Puerto Rico Islanders); Andrew Gregor (Seattle Sounders)
G: Greg Sutton (Montreal Impact) (Goalkeeper of the Year)
Coach: Michael Anhaeuser (Charleston Battery) (Coach of the Year)
Second Team
F: Alen Marcina (Puerto Rico Islanders); Greg Simmonds (Virginia Beach Mariners)
M: Leonardo Di Lorenzo (Montreal Impact); Jeff Clarke (Vancouver Whitecaps); Rodrigo Rios (Atlanta Silverbacks); Gavin Glinton (Charleston Battery))
D: Nevio Pizzolitto (Montreal Impact); Matt Bobo (Atlanta Silverbacks); Kenney Bertz (Rochester Raging Rhinos); Steve Klein (Vancouver Whitecaps)
G: Scott Vallow (Rochester Raging Rhinos)
Richmond Kickers won 2–1 on aggregate.----Charlotte Eagles won 6–1 on Aggregate.