| Champ: |  James Blake |
| Runner: | Andy Roddick |
| Score: | 4–6, 6–4, 7–6(7–5) |
| Draw: | 56 (4 / 4) |
| Seeds: | 16 |
| Type: | singles doubles |
| After Name: | Indianapolis Tennis Championships – Singles |
| Main Name: | Indianapolis Tennis Championships |
See main article: 2006 RCA Championships.
Robby Ginepri was the defending champion, but lost to Andy Roddick in the semifinals.
James Blake won in the final 4–6, 6–4, 7–6(7–5), against Andy Roddick.
All seeds receive a bye into the second round.