| Club: | Sevilla FC |
| Season: | 2005–06 |
| Manager: |  Juande Ramos |
| Stadium: | Ramón Sánchez Pizjuán |
| League: | La Liga |
| League Result: | 5th |
| Cup1: | Copa del Rey |
| Cup1 Result: | Round of 16 |
| Cup2: | UEFA Cup |
| Cup2 Result: | Winners |
| League Topscorer: | Javier Saviola (9) |
| Season Topscorer: | Frédéric Kanouté (14) |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
Sevilla came on fifth place in the domestic league with 68 points in total. Fourth-placed Osasuna also got 68 points, but won one more game. In the Copa del Rey, the team lost in the round of 16 against Cádiz. In the UEFA Cup, the team won their first ever European tournament by defeating Middlesbrough by 4–0 in the final.
| In (5 players) | ||
|---|---|---|
| Player | From | Fee |
 Frédéric Kanouté | Tottenham | €6.5M |
 Ivica Dragutinović |  Standard Liège | |
 Luis Fabiano | Porto | |
 Enzo Maresca | Fiorentina | €2.5M |
| Andrés Palop | Valencia | |
Squad at end of season
See main article: 2005–06 La Liga.
See main article: article and 2005–06 Copa del Rey.
See main article: 2005–06 UEFA Cup.
See main article: 2005–06 UEFA Cup first round.
See main article: 2005–06 UEFA Cup group stage.
See main article: 2005–06 UEFA Cup knockout stage.
See main article: 2006 UEFA Cup Final.