The 2005–06 EHF Women's Cup Winners' Cup was the 30th edition of EHF's competition for women's handball national cup champions. It ran from October 1, 2005 to May 20, 2006.
1985 champion Budućnost Podgorica, now representing Serbia and Montenegro, won its third European trophy and the first one since the break-up of Yugoslavia, beating Győri ETO, which defeated defending champion Larvik HK in the semifinals. It was Győri ETO's fourth lost European final in five years.[1]
First preliminary round. October 1–9, 2005
| width=35% | Local team | Aggregate | width=35% | Away team | 1st leg | 2nd leg |
|---|---|---|---|---|---|---|
McDonald's Wiener Neustadt  | 51–41 | 29–21 | 22–20 | |||
Váci NKSE  | 60–52 | 33–24 | 27–28 | |||
| 47–81 | HC Naisa | 22–38 | 25–43 | |||
| 29–85 | Bayer Leverkusen | 13–44 | 16–41 | |||
UMF Stjarnan  | 66–67 |  Anadolu Üniversitesi | 39–34 | 27–33 | ||
Zaglebie Lubin  | 73–39 | 30–16 | 43–23 | |||
| Amicitia Zürich | 48–37 | 25–19 | 23–18 | |||
| Rapid Bucharest | 97–33 | 52–13 | 45–20 | |||
Galychanka Lviv  | 50–54 | Ormi Patras | 26–27 | 24–27 | ||
Sola HK  | 90–26 | 53–11 | 37–15 | |||
Kuban Krasnodar  | 72–43 | 38–27 | 34–16 | |||
SD Itxako  | 83–15 | 40–10 | 43–5 | |||