| Team: | Edmonton Eskimos |
| Year: | 2001 |
| Record: | 9–9–0–1 |
| Division Place: | 1st, West |
| Coach: | Tom Higgins |
| General Manager: | Tom Higgins |
| Stadium: | Commonwealth Stadium |
| Playoffs: | Lost West Final |
| Mop: | John Avery, RB |
| Moc: | Sean Fleming, P/K |
| Mor: | Kelvin Powell, LB |
| Uniform: | Image:CFL EDM Jersey 1996.png |
| Shortnavlink: | Eskimos seasons |
The Edmonton Eskimos finished first in the West Division with a 9–9–0–1 record, but lost the West Final to the Calgary Stampeders. This season's Eskimos became the first West Division team in CFL history to finish first in the division with only a .500 record.
| Round | Pick | Player | Position | School/Club Team |
|---|---|---|---|---|
| 1 | 5 | DT | McGill | |
| 2 | 13 | CB | Toledo | |
| 3 | 21 | OL | Saskatchewan | |
| 5 | 37 | DL | Alberta | |
| 6 | 45 | DB | Bishop's | |
| Date | Visitor | Score | Home | OT | Attendance | |
| A | June 20 | Edmonton Eskimos | 34–10 | 29,090 | ||
| B | June 27 | 24–9 | Edmonton Eskimos | 28,579 | ||
| Edmonton Eskimos | 18 | 9 | 9 | 0 | 1 | 439 | 463 | 19 | Details | |
| Calgary Stampeders | 18 | 8 | 10 | 0 | 1 | 478 | 476 | 17 | Details | |
| BC Lions | 18 | 8 | 10 | 0 | 0 | 417 | 445 | 16 | Details | |
| 18 | 6 | 12 | 0 | 0 | 308 | 416 | 12 | Details |
| Week | Date | Visitor | Score | Home | OT | Attendance | Record | Pts | |
| 1 | July 7 | Edmonton Eskimos | 28–35 | OT | 18,125 | 0–1–0–1 | 1 | ||
| 2 | July 13 | 11–13 | Edmonton Eskimos | 32,722 | 1–1–0–1 | 3 | |||
| 3 | July 20 | 23–33 | Edmonton Eskimos | 33,524 | 2–1–0–1 | 5 | |||
| 4 | July 26 | Edmonton Eskimos | 6–34 | 19,541 | 2–2–0–1 | 5 | |||
| 5 | Aug 2 | Edmonton Eskimos | 24–14 | 17,107 | 3–2–0–1 | 7 | |||
| 6 | Aug 11 | Edmonton Eskimos | 39–42 | BC Lions | 18,171 | 3–3–0–1 | 7 | ||
| 7 | Aug 17 | BC Lions | 35–17 | Edmonton Eskimos | 35,394 | 3–4–0–1 | 7 | ||
| 8 | Aug 24 | Hamilton Tiger-Cats | 20–12 | Edmonton Eskimos | 37,666 | 3–5–0–1 | 7 | ||
| 9 | Sept 3 | Edmonton Eskimos | 33–32 | Calgary Stampeders | 35,967 | 4–5–0–1 | 9 | ||
| 10 | Sept 7 | Calgary Stampeders | 34–33 | Edmonton Eskimos | 48,279 | 4–6–0–1 | 9 | ||
| 11 | Sept 17 | Edmonton Eskimos | 22–23 | 26,144 | 4–7–0–1 | 9 | |||
| 12 | Sept 21 | 22–23 | Edmonton Eskimos | 28,687 | 5–7–0–1 | 11 | |||
| 13 | Sept 29 | Edmonton Eskimos | 35–19 | Saskatchewan Roughriders | 18,086 | 6–7–0–1 | 13 | ||
| 14 | Oct 5 | Winnipeg Blue Bombers | 37–33 | Edmonton Eskimos | 29,659 | 6–8–0–1 | 13 | ||
| 15 | Oct 12 | BC Lions | 22–28 | Edmonton Eskimos | 30,518 | 7–8–0–1 | 15 | ||
| 16 | Oct 19 | Edmonton Eskimos | 25–22 | Toronto Argonauts | OT | 15,438 | 8–8–0–1 | 17 | |
| 17 | Oct 27 | Edmonton Eskimos | 3–12 | Saskatchewan Roughriders | 20,917 | 8–9–0–1 | 17 | ||
| 18 | Nov 4 | Montreal Alouettes | 26–32 | Edmonton Eskimos | 43,123 | 9–9–0–1 | 19 |
Total attendance: 319,572
Average attendance: 35,510 (59.1%)
| Week | Date | Visitor | Score | Home | OT | Attendance | |
| Division Final | Nov 18 | Calgary Stampeders | 34–16 | Edmonton Eskimos | 42,156 |