| 2-hydroxymuconate-semialdehyde hydrolase | |
| Ec Number: | 3.7.1.9 |
| Cas Number: | 54004-61-4 |
| Go Code: | 0018775 |
In enzymology, a 2-hydroxymuconate-semialdehyde hydrolase is an enzyme that catalyzes the chemical reaction
2-hydroxymuconate semialdehyde + H2O
\rightleftharpoons
Thus, the two substrates of this enzyme are 2-hydroxymuconate semialdehyde and H2O, whereas its two products are formate and 2-oxopent-4-enoate.
This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2-hydroxymuconate-semialdehyde formylhydrolase. Other names in common use include 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase, 2-hydroxymuconic semialdehyde hydrolase, HMSH, and HOD hydrolase. This enzyme participates in 5 metabolic pathways: benzoate degradation via hydroxylation, toluene and xylene degradation, 1,4-dichlorobenzene degradation, carbazole degradation, and styrene degradation.
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,, and .