| Tourney Name: | Copa Merconorte |
| Yearr: | 1999 |
| Dates: | 28 July – 22 December 1999 |
| Num Teams: | 12 |
| Associations: | 5 |
| Champion Other: |  América de Cali |
| Count: | 1 |
| Second Other: | Santa Fe |
| Matches: | 42 |
| Goals: | 122 |
| Top Scorer: |  Juan Enrique García (6) |
| Prevseason: | 1998 |
| Nextseason: | 2000 |
The 1999 Copa Merconorte was the 2nd edition of association football tournament Copa Merconorte held in 1999. América de Cali of Colombia beat Santa Fe also of Colombia in the final.
| width=125 | Country | width=150 | Team |
|---|---|---|---|
(1 berth) | The Strongest | ||
(4 berths) | América de Cali | ||
| Atlético Nacional | |||
| Millonarios | |||
| Santa Fe | |||
(3 berths) | |||
| El Nacional | |||
(3 berths) | |||
| Sporting Cristal | |||
(1 berth) | Caracas | ||
Each team played the other teams in the group twice during the group stage. The first place team advanced to the second round.
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