| Champ: |  Lindsay Davenport |
| Runner: | Martina Hingis |
| Score: | 6–3, 6–4 |
| Type: | singles doubles |
The 1999 Advanta Championships of Philadelphia singles was the tennis singles event of the seventeenth edition of the Advanta Championships of Philadelphia; a WTA Tier II tournament held in Philadelphia. Steffi Graf was the defending champion but retired after Wimbledon earlier in the year.
After losing in last year's final, World No. 2 Lindsay Davenport won the title this year, defeating World No. 1 Martina Hingis, 6–3, 6–4.
The top four seeds received a bye to the second round.