Mary Pierce defeated Monica Seles in the final, 7–6(7–2), 6–3 to win the women's singles tennis title at the 1998 Kremlin Cup.
Jana Novotná was the reigning champion, but chose not to compete that year.
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. The top four seeds received a bye to the second round.
Venus Williams (semifinals) Monica Seles (final)
Conchita Martínez (quarterfinals)
Mary Pierce (champion)
Anna Kournikova (first round) Sandrine Testud (semifinals)