| Year: | 1991 |
| Team: | Duke Blue Devils |
| Sport: | football |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Record: | 4–6–1 |
| Conf Record: | 1–6 |
| Head Coach: | Barry Wilson |
| Hc Year: | 2nd |
| Off Coach: | Eddie Wilson |
| Oc Year: | 2nd |
| Def Coach: | Dale Strahm |
| Dc Year: | 2nd |
| Mvp: | Dave Brown |
| Captain: | Erwin Sampson, Pete Petroff |
| Stadium: | Wallace Wade Stadium |
The 1991 Duke Blue Devils football team represented Duke University as a member of the Atlantic Coast Conference (ACC) during the 1991 NCAA Division I-A football season. Led by second-year head coach Barry Wilson, the Blue Devils compiled an overall record of 4–6–1 with a mark of 1–6 in conference play, and finished tied for seventh in the ACC. Duke played home games at Wallace Wade Stadium in Durham, North Carolina.