| Year: | 1988 |
| Team: | Wyoming Cowboys |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Coachrank: | 20 |
| Record: | 11–2 |
| Conf Record: | 8–0 |
| Head Coach: | Paul Roach |
| Hc Year: | 2nd |
| Off Coach: | Joe Tiller |
| Oc Year: | 2nd |
| Stadium: | War Memorial Stadium |
| Champion: | WAC champion |
| Bowl: | Holiday Bowl |
| Bowl Result: | L 14–62 vs. Oklahoma State |
The 1988 Wyoming Cowboys football team represented the University of Wyoming in the 1988 NCAA Division I-A football season. It was the Cowboys' 93rd season and they competed as a member of the Western Athletic Conference (WAC). The team was led by head coach Paul Roach, in his second year, and played their home games at War Memorial Stadium in Laramie, Wyoming. The Cowboys won the first 10 games of the season, with an average margin of victory of 30 points, claiming the WAC championship with an undefeated 8–0 record, and reaching a #10 ranking in the national AP poll.[1] However, the season ended with two disastrous losses in the last three games, including a 62–14 rout by Oklahoma State (led by Heisman Trophy winner Barry Sanders) in the Holiday Bowl. The Cowboys offense scored 511 points, while the defense allowed 280 points.
The following were selected in the 1989 NFL draft.
| Player | Position | Round | Overall | NFL team |
| Eric Coleman | Defensive back | 2 | 43 | |
| David Edeen | Defensive end | 5 | 128 | |
| Pat Rabold | Defensive tackle | 9 | 249 | |