The 1980–81 United Counties League season was the 74th in the history of the United Counties League, a football competition in England. At the end of the previous season reserve teams from Division One were transferred to newly established reserve division, they were replaced by clubs from Division Two.
| Competition: | United Counties League Premier Division |
| Season: | 1980–81 |
| Winners: | Stamford |
| Relegated: | Northampton Spencer |
| Matches: | 306 |
| Total Goals: | 986 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The Premier Division featured 18 clubs which competed in the division last season, no new clubs joined the division this season.
| Competition: | United Counties League Division One |
| Season: | 1980–81 |
| Winners: | Stevenage Borough |
| Promoted: | Stevenage Borough British Timken Duston |
| Matches: | 272 |
| Total Goals: | 976 |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
Division One featured nine clubs which competed in the division last season, along with eight new clubs.
Also, Irchester United changed name to Irchester Eastfield.