| Year: | 1978 |
| Team: | Wyoming Cowboys |
| Sport: | football |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Record: | 5–7 |
| Conf Record: | 4–2 |
| Head Coach: | Bill Lewis |
| Hc Year: | 2nd |
| Captain: | Ken Fantetti, Marc Cousins |
| Stadium: | War Memorial Stadium |
The 1978 Wyoming Cowboys football team was an American football team that represented the University of Wyoming as a member of the Western Athletic Conference (WAC) during the 1978 NCAA Division I-A football season. In their second season under head coach Bill Lewis, the Cowboys compiled a 5–7 record (4–2 against conference opponents), finished third out of seven teams in the WAC, and outscored opponents by a total of 253 to 245. They played their home games at War Memorial Stadium in Laramie, Wyoming.[1]