| Election Name: | 1968 United States Senate election in South Carolina |
| Country: | South Carolina |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1966 United States Senate special election in South Carolina |
| Previous Year: | 1966 (special) |
| Next Election: | 1974 United States Senate election in South Carolina |
| Next Year: | 1974 |
| Election Date: | November 5, 1968 |
| Image1: | Ernest Hollings 91st Congress.jpg |
| Nominee1: | Ernest Hollings |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 404,060 |
| Percentage1: | 61.89% |
| Nominee2: | Marshall Parker |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 248,780 |
| Percentage2: | 38.11% |
| Map Size: | 220px |
| U.S. Senator | |
| Before Election: | Ernest Hollings |
| Before Party: | Democratic Party (United States) |
| After Election: | Ernest Hollings |
| After Party: | Democratic Party (United States) |
The 1968 South Carolina United States Senate election was held on November 5, 1968, to select the U.S. Senator from the state of South Carolina. Incumbent Democratic Senator Fritz Hollings easily defeated Republican state senator Marshall Parker in a rematch of the election two years earlier to win his second, (his first full), term.
Fritz Hollings, the incumbent Senator, easily defeated his primary opponent, John Bolt Culberson.[1]
Marshall Parker, the state senator from Oconee County in the Upstate, was persuaded by South Carolina Republicans to enter the race and he did not face a primary challenge.
After a close election loss to Fritz Hollings in 1966, the Republicans felt that Parker might have a chance at defeating Hollings by riding Nixon's coattails in the general election. However, the Republicans did not provide Parker with the financial resources to compete and he subsequently lost by a bigger margin to Hollings than two years prior.
|-| | colspan=5 |Democratic hold|-