| Year: | 1965 |
| Team: | Oklahoma Sooners |
| Sport: | football |
| Conference: | Big Eight Conference |
| Short Conf: | Big 8 |
| Record: | 3–7 |
| Conf Record: | 3–4 |
| Head Coach: | Gomer Jones |
| Hc Year: | 2nd |
| Captain: | Carl McAdams |
| Captain2: | Mike Ringer |
| Stadium: | Oklahoma Memorial Stadium |
The 1965 Oklahoma Sooners football team represented the University of Oklahoma during the 1965 NCAA University Division football season. Led by second-year head coach Gomer Jones, they played their home games at Oklahoma Memorial Stadium and competed as members of the Big Eight Conference.
A longtime assistant under Bud Wilkinson, Jones resigned after the 3–7 season, one of the worst in program history,[1] but remained at OU as athletic director.[2]
Jim Mackenzie, an assistant at Arkansas under Frank Broyles, was hired as head coach in December.[2]
The following players were drafted by National Football League teams on November 27, 1965.[4]
| 1 | 8 | Carl McAdams | Linebacker | St. Louis Cardinals | |
| 10 | 149 | Mike Ringer | Running back | St. Louis Cardinals |