The 1953–54 Macedonian Republic League was the tenth since its establishment. Pobeda Prilep won their second championship title.
| Club | City | |
|---|---|---|
| Belasica | Strumica | |
| Bregalnica | Shtip | |
| Crvena Dzvezda | Veles | |
| Karaorman | Struga | |
| Metalec | Skopje | |
| Napredok | Kumanovo | |
| Ohrid | Ohrid | |
| Rabotnik | Bitola | |
| Pobeda | Prilep | |
| Sloga | Skopje | |
| Tekstilec | Skopje | |
| Tikvesh | Kavadarci |
Karovski, Ilija (1996) FK Tikvesh 1930–1995 p. 42, 43, 44, 45