| Election Name: | 1952 United States Senate election in California |
| Country: | California |
| Flag Image: | Flag of California (1924–1953).pngborder |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1946 United States Senate election in California |
| Previous Year: | 1946 |
| Next Election: | 1958 United States Senate election in California |
| Next Year: | 1958 |
| Election Date: | November 4, 1952 |
| Image1: | Portrait of California Senator William F. Knowland (cropped).jpg |
| Nominee1: | William F. Knowland |
| Party1: | Republican Party (US) |
| Alliance1: | Democratic Party (US) |
| Popular Vote1: | 3,982,448 |
| Percentage1: | 87.79% |
| Nominee2: | Reuben W. Borough |
| Party2: | Progressive Party (US, 1948) |
| Popular Vote2: | 542,270 |
| Percentage2: | 11.95% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | William F. Knowland |
| Before Party: | Republican Party (US) |
| After Election: | William F. Knowland |
| After Party: | Republican Party (US) |
The 1952 United States Senate election in California was held on November 4, 1952, concurrently with the 1952 U.S. presidential election as well as other elections to the United States Senate and House of Representatives and various state and local elections.
By cross-filing and winning the Democratic nomination, incumbent Republican Senator William F. Knowland was able to cruise to a general election victory with only nominal opposition.
Until 1988, this was the last time a nominee from either party won re-election to this seat.