| Election Name: | 1950 United States Senate election in South Dakota |
| Country: | South Dakota |
| Flag Year: | 1909 |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1944 United States Senate election in South Dakota |
| Previous Year: | 1944 |
| Next Election: | 1956 United States Senate election in South Dakota |
| Next Year: | 1956 |
| Election Date: | November 7, 1950 |
| Image1: | File:Francis Higbee Case.jpg |
| Nominee1: | Francis Case |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 160,670 |
| Percentage1: | 63.92% |
| Nominee2: | John A. Engel |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 90,692 |
| Percentage2: | 36.08% |
| Map Size: | 240px |
| U.S. Senator | |
| Before Election: | Chan Gurney |
| Before Party: | Republican Party (United States) |
| After Election: | Francis Case |
| After Party: | Republican Party (United States) |
The 1950 United States Senate election in South Dakota took place on November 7, 1950. Incumbent Republican senator Chan Gurney ran for re-election to a third term. He was challenged in the Republican primary by Congressman Francis H. Case, who had represented the 2nd District since 1939. In the general election, Case faced John A. Engel, an attorney and the 1948 Democratic nominee for the U.S. Senate. As the Republican Party was making significant gains nationwide, Case defeated Engel in a landslide.