| Year: | 1950 |
| Team: | Mississippi Southern Southerners |
| Sport: | football |
| Conference: | Gulf States Conference |
| Short Conf: | GSC |
| Record: | 5–5 |
| Conf Record: | 3–1 |
| Head Coach: | Thad Vann |
| Hc Year: | 2nd |
| Stadium: | Faulkner Field |
| Champion: | GSC champion |
The 1950 Mississippi Southern Southerners football team was an American football team that represented Mississippi Southern College (now known as the University of Southern Mississippi) as a member of the Gulf States Conference during the 1950 college football season. In their second year under head coach Thad Vann, the team compiled a 5–5 record.