| Type: | GP |
| Grand Prix: | Czechoslovakia |
| Date: | 25 September |
| Year: | 1949 |
| Official Name: | I Velká cena Československa |
| Country: | Czechoslovakia |
| Location: | Brno, Czechoslovakia |
| Course: | Road course |
| Course Mi: | 11.1 |
| Course Km: | 17.8 |
| Distance Laps: | 20 |
| Distance Mi: | 221.21 |
| Distance Km: | 356.01 |
| Pole Driver: | Prince Bira |
| Pole Team: | Maserati 4CLT/48 |
| Pole Country: | Thailand |
| Pole Time: | Drawn |
| Fast Driver: | Prince Bira |
| Fast Team: | Maserati 4CLT/48 |
| Fast Time: | 8:03.0 |
| Fast Country: | Thailand |
| Fast Driver2: | Emmanuel de Graffenried |
| Fast Team2: | Maserati 4CLT/48 |
| Fast Country2: | Switzerland |
| First Driver: | Peter Whitehead |
| First Team: | Ferrari 125 |
| First Country: | United Kingdom |
| Second Driver: | Philippe Étancelin |
| Second Team: | Talbot-Lago T26C |
| Second Country: | France |
| Third Driver: | Franco Cortese |
| Third Team: | Ferrari F2 |
| Third Country: | Italy |
The I Velká cena Československa was a Grand Prix motor race which was held at Masaryk Circuit on 25 September 1949. The race was won by Peter Whitehead driving a Ferrari 125.Czechoslovak driver Václav Uher died in crash during practice. Giuseppe Farina crashed into spectators in the first lap of the race and killed two of them. Tatraplan of Bruno Sojka was in streamlined configuration.
| Pos | No | Driver | Constructor | Laps | Time/Retired | Grid |
|---|---|---|---|---|---|---|
| 1 | 14 |  Peter Whitehead | Ferrari 125 | 20 | 2:48:41.0 | 8 |
| 2 | 3 |  Philippe Étancelin | Talbot-Lago T26C | 20 | +35.6 | 5 |
| 3 | 15 |  Franco Cortese | Ferrari 166S | 20 | + 4:49.4 | 17 |
| 4 | 2 | Pierre Levegh | Talbot-Lago T26C | 19 | + 1 Lap | 13 |
| 5 | 8 | Henri Louveau | Maserati 4CL | 19 | + 1 Lap | 23 |
| 6 | 1 |  Johnny Claes | Talbot-Lago T26C | 19 | + 1 Lap | 12 |
| 7 | 6 | Piero Carini | Maserati 4CLT/48 | 19 | + 1 Lap | 14 |
| 8 | 4 | Louis Rosier | Talbot-Lago T26C | 19 | + 1 Lap | 11 |
| 9 | 22 | Bruno Sojka | Tatraplan | 18 | + 2 Laps | 18 |
| 10 | 26 | Jaroslav Vlček | Magda II-Fiat | 17 | + 3 Laps | 20 |
| 11 | 27 | František Dobrý | BMW 328 | 17 | + 3 Laps | 19 |
| Ret | 9 | Emmanuel de Graffenried | Maserati 4CLT/48 | 13 | Engine | 3 |
| Ret | 11 | David Murray | Maserati 4CLT | 13 | Engine | 16 |
| Ret | 17 | Maurice Trintignant | Simca-Gordini | 9 | Accident | 9 |
| Ret | 7 | Louis Chiron | Maserati 4CLT | 8 | Gearbox | 4 |
| Ret | 24 | Antonín Komár | Cisitalia D46 | ? | ? | 21 |
| Ret | 18 | Robert Manzon | Simca-Gordini | 4 | Valve | 6 |
| Ret | 10 |  B. Bira | Maserati 4CLT/48 | 3 | Accident | 1 |
| Ret | 19 | Zdeněk Trejbal | Simca-Gordini | 2 | Engine | 10 |
| Ret | 41 | Aldo Gordini | Simca-Gordini | 1 | ? | 15 |
| Ret | 23 | Vladimír Formánek | Cisitalia D46 | 1 | ? | 22 |
| Ret | 12 | Reg Parnell | Maserati 4CLT | 1 | Accident | 7 |
| Ret | 5 | Giuseppe Farina | Maserati 4CLT/48 | 1 | Accident | 2 |
| DNS | - |  Luigi Chinetti | Ferrari 125 | - | ? | - |
| DNS | - | Marc Versini | Delage | - | ? | - |
| DNS | 21 | Jiří Pohl | MG K | - | ? | - |
| DNS | 25 | Václav Uher | Maserati 6CM | - | Fatal practice accident | - |
| DNS | 28 | Karel Vlašín | Mono J.K. | - | Collision with truck in practice | - |
| DNS | 16 | Boško Milenković | Bugatti T51 | - | Started unofficially | - |
| DNS | 29 | Yuri Sidorov | Tatraplan | - | Not present | - |