| Competition: | Primera División de México |
| Season: | 1949–50 |
| Winners: | Veracruz (2nd title) |
| Matches: | 182 |
| Total Goals: | 734 |
| Prevseason: | 1948–49 |
| Nextseason: | 1950–51 |
Statistics of the Primera División de México for the 1949–50 season.
It was contested by 14 teams, and Veracruz won the championship.
| Team | City | Stadium | |
|---|---|---|---|
| América | Mexico City | Ciudad de los Deportes | |
| Atlante | Mexico City | Ciudad de los Deportes | |
| Atlas | Guadalajara, Jalisco | Parque Oblatos | |
| Asturias | Mexico City | Parque Asturias | |
| Club España | Mexico City | Campo España | |
| Guadalajara | Guadalajara, Jalisco | Parque Oblatos | |
| León | León, Guanajuato | Enrique Fernández Martínez | |
| Marte | Mexico City | Ciudad de los Deportes | |
| Moctezuma | Orizaba, Veracruz | Campo Moctezuma | |
| Oro | Guadalajara, Jalisco | Parque Oblatos | |
| Puebla | Puebla, Puebla | Parque El Mirador | |
| San Sebastián | León, Guanajuato | Enrique Fernández Martínez | |
| C.D. Tampico | Tampico, Tamaulipas | Tampico | |
| Veracruz | Veracruz, Veracruz | Parque Deportivo Veracruzano |
After this season Asturias, Club España, and Moctezuma retired from the league due to differences with the Federation. Necaxa, an old member and who didn't accept professionalism in 1943, re-joined for next season.