| Year: | 1948 |
| Team: | Eastern Illinois Panthers |
| Sport: | football |
| Conference: | Illinois Intercollegiate Athletic Conference |
| Short Conf: | IIAC |
| Record: | 7–3 |
| Conf Record: | 4–0 |
| Head Coach: | Maynard O'Brien |
| Hc Year: | 3rd |
| Champion: | IIAC champion |
| Bowl: | Corn Bowl |
| Bowl Result: | L 0–6 vs. |
The 1948 Eastern Illinois Panthers football team represented Eastern Illinois State College—now known as Eastern Illinois University—as a member of the Illinois Intercollegiate Athletic Conference (IIAC) during the 1948 college football season. Led by third-year head coach Maynard O'Brien, the Panthers finished the season with a 7–3 record overall and a 4–0 mark in conference play, winning the IIAC. They were invited to the postseason Corn Bowl, where they lost to, 6–0.[1]
Eastern Illinois was ranked at No. 187 in the final Litkenhous Difference by Score System ratings for 1948.[2]