| Champ: |  Jack Kramer[1] |
| Score: | 9–7, 6–3, 6–0 |
Jack Kramer defeated Tom Brown 9–7, 6–3, 6–0 in the final to win the men's singles tennis title at the 1946 U.S. National Championships.[2]
The seeded players are listed below. Jack Kramer is the champion; others show the round in which they were eliminated.
Frank Parker (quarterfinals) Jack Kramer (champion) Gardnar Mulloy (semifinals) Bill Talbert (quarterfinals) Donald McNeill (quarterfinals) Tom Brown (finalist)
Pancho Segura (quarterfinals) Robert Falkenburg (semifinals) Seymour Greenberg (fourth round) Frank Guernsey (third round)
Yvon Petra (second round)
Alejo Russell (fourth round) Pierre Pellizza (fourth round) Enrique Morea (first round)
Harry Hopman (second round) Bernard Destremau (first round)
Philippe Washer (second round) Robert Barnes (third round)
Derrick Barton (third round)