| National Challenge Cup | |
| Year: | 1946 |
| Country: | United States |
| Dates: | 6 January – 14 July 1946 |
| Defending Champions: | Brookhattan |
| Winners: | Chicago Viking F.C. |
| Second: | Ponta Delgada S.C. |
| Semifinal1: | Heidelberg S.C. |
| Semifinal2: | Philadelphia Americans |
| Prev Season: | 1945 |
| Next Season: | 1947 |
The 1946 National Challenge Cup was the 33rd edition of the United States Football Association's annual open cup. The Chicago Viking F.C. defeated the Ponta Delgada S.C. to win.