| Competition: | Liga Mayor |
| Season: | 1941–42 |
| Winners: | Real España (6th title) |
| Matches: | 57 |
| Total Goals: | 293 |
| League Topscorer: | Rafael Meza (20 goals) |
| Prevseason: | 1940–41 |
| Nextseason: | 1942–43 |
The 1941-42 season was the edition XX of the league's amateur era called Liga Mayor.
The playoff match to define the title was held at Parque Asturias on May 10, 1942.