| Election Name: | 1928 United States Senate special election in Ohio |
| Country: | Ohio |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1926 United States Senate election in Ohio |
| Previous Year: | 1926 |
| Next Election: | 1930 United States Senate special election in Ohio |
| Next Year: | 1930 (special) |
| Election Date: | November 6, 1928 |
| Image1: | TheodoreEBurton (1).jpg |
| Nominee1: | Theodore E. Burton |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 1,429,554 |
| Percentage1: | 62.43% |
| Nominee2: | Graham P. Hunt |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 856,807 |
| Percentage2: | 37.42% |
| U.S. Senator | |
| Before Election: | Cyrus Locher |
| Before Party: | Democratic Party (United States) |
| After Election: | Theodore E. Burton |
| After Party: | Republican Party (United States) |
The 1928 United States Senate special election in Ohio was held on November 6, 1928, to elect a successor to Frank B. Willis, who died in office in March 1928. Republican U.S. Representative Theodore E. Burton, who previously held this seat from 1909 to 1915, won the open race to succeed him.
Incumbent Republican Senator Frank B. Willis died in office on March 30, 1928. Governor of Ohio Vic Donahey appointed Cyrus Locher to fill the vacant seat until a successor could be duly elected. The special election to fill the seat was scheduled for November 6, 1928, concurrent with the general election for President of the United States, Governor, and Ohio's other U.S. Senate seat.
The primary was contested over the issue of Prohibition; Locher was an advocate of the policy, allied with the Anti-Saloon League, while Hunt was an opponent.[1]