| Year: | 1921 |
| Team: | Wyoming Cowboys |
| Sport: | football |
| Conference: | Rocky Mountain Conference |
| Short Conf: | RMC |
| Record: | 1–4–2 |
| Conf Record: | 1–3–2 |
| Head Coach: | John Corbett |
| Hc Year: | 6th |
| Captain: | Robert Steele Wilson |
The 1921 Wyoming Cowboys football team was an American football team that represented the University of Wyoming as a member of the Rocky Mountain Conference (RMC) during the 1921 college football season. In their sixth season under head coach John Corbett, the Cowboys compiled a 1–4–2 record (1–3–2 against conference opponents), finished seventh in the RMC, and were outscored by a total of 92 to 39. Robert Steele Wilson was the team captain.[1] [2]