| Election Name: | 1916 United States Senate election in Pennsylvania |
| Country: | Pennsylvania |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1911 United States Senate election in Pennsylvania |
| Previous Year: | 1911 |
| Next Election: | 1922 United States Senate elections in Pennsylvania |
| Next Year: | 1922 |
| Election Date: | November 7, 1916 |
| Image1: | Image:Philander C Knox-H&E.jpg |
| Nominee1: | Philander C. Knox |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 680,451 |
| Percentage1: | 56.31% |
| Nominee2: | Ellis L. Orvis |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 450,112 |
| Percentage2: | 37.25% |
| U.S. Senator | |
| Before Election: | George T. Oliver |
| Before Party: | Republican Party (United States) |
| After Election: | Philander C. Knox |
| After Party: | Republican Party (United States) |
The 1916 United States Senate election in Pennsylvania was held on November 7, 1916. Incumbent Republican U.S. Senator George T. Oliver was not a candidate for re-election.
The Republican nominee, Philander C. Knox, defeated Democratic nominee Ellis C. Orvis.
Knox subsequently died in October 1921, during his first term,[1] and William E. Crow was appointed to fill the vacancy. Crow then also died before the expiration of the term, in August 1922.[2]
David A. Reed was then appointed to fill the vacancy created by Crow's death, and was subsequently elected to complete the rest of the term expiring in March 1923 and to a full six-year term in his own right on the same day.[3]