| Year: | 1912 |
| Team: | Ole Miss Rebels |
| Sport: | football |
| Conference: | Southern Intercollegiate Athletic Association |
| Short Conf: | SIAA |
| Record: | 5–3 |
| Conf Record: | 2–2 |
| Head Coach: | Leo DeTray |
| Hc Year: | 1st |
| Captain: | John C. Adams |
The 1912 Ole Miss Rebels football team represented the University of Mississippi as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1912 college football season. Led by Leo DeTray in his first and only season as head coach, the Rebels compiled an overall record of 5–3 with a mark of 2–2 in SIAA play.
| John C. Adams | center | |
| Rube Barker | tackle | |
| J. P. Evans | end | |
| E. F. McCall | guard | |
| L. D. Myers | tackle | |
| H. A. Puryear | guard | |
| E. S. Samuels | guard | |
| Guy Spruhan | end | |
| J. S. Therrell | end | |
| W. E. Vandevere | end |
| J. J. Breeland | halfback | |
| David Gardner | halfback | |
| W. G. Green | halfback | |
| Ralph E. Fletcher | quarterback | |
| M. F. Haralson | quarterback | |
| I. H. Harris | fullback | |
| R. K. Haxton | halfback | |
| G. J. Leftwich | fullback |