| Country: | Chile |
| Type: | presidential |
| Previous Election: | 1876 Chilean presidential election |
| Previous Year: | 1876 |
| Next Election: | 1886 Chilean presidential election |
| Next Year: | 1886 |
| Election Date: | 1881 |
| Image1: | Domingo Santa María 1885.jpg |
| Party1: | Liberal–Radical |
| Candidate1: | Domingo Santa María |
| Electoral Vote1: | 255 |
| Percentage1: | 95.51% |
| President | |
| Before Election: | Aníbal Pinto |
| Before Party: | National–Liberal |
| After Election: | Domingo Santa María |
| After Party: | Liberal–Radical |
| Candidate2: | Manuel Baquedano |
| Party2: | Conservative–Liberal |
| Electoral Vote2: | 12 |
| Percentage2: | 4.49% |
Presidential elections were held in Chile in 1881,[1] during the War of the Pacific. Carried out through a system of electors, they resulted in the election of Domingo Santa María as president. Santa María was the sole candidate after Manuel Baquedano's resignation. However, Baquedano received 12 electoral votes in Santiago.