Kentucky gained two seats in reapportionment following the 1820 United States census. Kentucky elected its members August 5, 1822.
| District | Incumbent | This race | ||||||
|---|---|---|---|---|---|---|---|---|
| Member | Party | First elected | Results | Candidates | ||||
| David Trimble | Democratic-Republican | 1816 | Incumbent re-elected. | nowrap | ||||
| Thomas Metcalfe | Democratic-Republican | 1818 | Incumbent re-elected. | nowrap | ||||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | ||||||
| John S. Smith | Democratic-Republican | 1821 (Special) | Incumbent lost re-election. New member elected. Democratic-Republican hold. | nowrap | ||||
| John T. Johnson | Democratic-Republican | 1820 | Incumbent re-elected. | nowrap | ||||
| None (District created) | New seat. New member elected. Adams Republican gain. | nowrap | ||||||
| Samuel H. Woodson | Democratic-Republican | 1820 | Incumbent lost re-election. New member elected. Democratic-Republican hold. | nowrap | ||||
| None (District created) | New seat. New member elected. Adams Republican gain. | nowrap | ||||||
| James D. Breckinridge | Democratic-Republican | 1821 (Special) | Incumbent lost re-election. New member elected. Democratic-Republican hold. | nowrap | ||||
| Francis Johnson | Democratic-Republican | 1820 | Incumbent re-elected. | nowrap | ||||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | ||||||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | ||||||