Α-PHiP explained

α-Pyrrolidinoisohexanophenone (mainly known as A-PiHP or α-PiHP) is a stimulant drug of the cathinone class that has been sold online as a designer drug. It acts as a potent norepinephrine-dopamine reuptake inhibitor (NDRI). In July 2016 α-PHiP was first identified as a designer drug[1] when it was reported to the EMCDDA by a forensic laboratory in Slovenia.[2] [3] It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. Similarly to other cathinones, use of α-PiHP can result in compulsive redosing, addiction, anxiety, paranoia, and psychosis.

Pharmacology

In a classic 2006 study of pyrrolidinyl cathinone derivatives by Meltzer et al. at Organix, the alpha-isobutyl derivative of pyrovalerone, O-2494, was found to have the highest potency in vitro as an inhibitor of the dopamine transporter of the alpha substituted derivatives tested.[4] Compared to α-PVP and α-PHP, α-PiHP displays a higher selectivity for the dopamine transporter.

See also

Notes and References

  1. Web site: July 2016 . Analytic Report alpha-PHiP (C16H23NO) 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one. . live . https://web.archive.org/web/20201003004736/https://www.policija.si/apps/nfl_response_web/0_Analytical_Reports_final/alpha-PHiP-ID-1723-16rpt071216.pdf . 2020-10-03 . 2019-10-24 . Nacionalni forenzični laboratorij . Slovenia.
  2. Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA . live . EMCDDA–Europol Joint Publication . https://web.archive.org/web/20210126100454/https://www.emcdda.europa.eu/system/files/publications/4724/TDAN17001ENN_PDFWEB.pdf . 2021-01-26 . 2019-10-24.
  3. Liu C, Jia W, Li T, Hua Z, Qian Z . August 2017 . Identification and analytical characterization of nine synthetic cathinone derivatives N-ethylhexedrone, 4-Cl-pentedrone, 4-Cl-α-EAPP, propylone, N-ethylnorpentylone, 6-MeO-bk-MDMA, α-PiHP, 4-Cl-α-PHP, and 4-F-α-PHP . Drug Testing and Analysis . 9 . 8 . 1162–1171 . 10.1002/dta.2136 . 27863142.
  4. Meltzer PC, Butler D, Deschamps JR, Madras BK . 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors . Journal of Medicinal Chemistry . 49 . 4 . 1420–32 . February 2006 . 16480278 . 2602954 . 10.1021/jm050797a .

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